| 包装: | 1mg |
| 市场价: | 3237元 |
Cell lines | Rat pituitary melanotropic cells |
Preparation Method | |
Reaction Conditions | 1 or 10 µM |
Applications | 1 µM ω-Conotoxin GVIA blocked the high voltage-activated current by 25.5±3.6%. The block at 10µM ω-Conotoxin GVIA was 22.9±2.5% (not significantly different from the block by 1µM;n = 3), indicating thatω-Conotoxin GVIA yields a saturating effect. |
Animal models | male COBS CD (SD) rats |
Preparation Method | In these animals the intravenous administration of graded doses of ω-Conotoxin GVIA (1--2 nmol/kg) |
Dosage form | Intravenous injection, 1--2 nmol/kg |
Applications | Intravenous injection caused a progressive loss of tension development of tibialis muscle indirectly evoked by the electrical stimulation of the sciatic nerve, ω-Conotoxin GVIA (1 nmol/kg i.v.) reduced the strength of muscle contraction by 75% in about 27 min (from |
| 产品描述 | ω-Conotoxin GVIA is a cone snail toxin that selectively blocks N-type channels in neurons[1]. ω-Conotoxin GVIA binds to human neocortical, rat hippocampal, and chick brain synaptic plasma membranes (IC50s = 4.6, 60, and 150 pM, respectively, in radioligand binding assays)[3,4,5]. ω-Conotoxin GVIA markedly reduced the amplitude of the tetanic contractions of the tibialis anterior muscle in mice, but tetanic facilitation was not impaired. The muscle contractions elicited by direct electrical stimulation were not significantly modified by ω-Conotoxin GVIA. ω-Conotoxin GVIA did not had any significant changes in systemic blood pressure[5]. References: |
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