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CALP1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CALP1图片
CAS NO:145224-99-3
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
CALP1 是一种钙调蛋白 (CaM) 激动剂（Kd 为 88 μM），可与 CaM EF-hand/Ca2+- 结合位点结合。
Cas No.145224-99-3
别名Calcium-like Peptide 1
化学名(2S,3Z,5S,6Z,8S,9Z,11S,12Z,14S,15Z,17S,18Z,20S,21Z,23S)-23-amino-2-(4-aminobutyl)-17-((S)-sec-butyl)-4,7,10,13,16,19,22-heptahydroxy-14-((R)-1-hydroxyethyl)-8-isobutyl-5,11-diisopropyl-20,24-dimethyl-3,6,9,12,15,18,21-heptaazapentacosa-3,6,9,12,15,18,21-h
Canonical SMILESCC[C@]([C@@](/N=C(O)/[C@](/N=C(O)/[C@](N)([H])C(C)C)([H])C)([H])/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](C(O)=O)([H])CCCCN)([H])C(C)C)([H])CC(C)C)([H])C(C)C)([H])[C@@](O)([H])C)([H])C
分子式C40H75N9O10
分子量842.09
溶解度0.5mg/mL in ethanol, 5mg/mL in DMF or in DMSO
储存条件Desiccate at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CALP1 is an 8-residue calcium-like peptide that interacts with an EF hand motif based on the troponin C superfamily calcium binding site.[1] It binds to calmodulin (Kd = 88 μM) and activates phosphodiesterase in the presence of calmodulin and absence of calcium. CALP1 also acts as a cell-permeable inhibitor of calcium influx through glutamate receptor channels in cultured rat neocortical neurons thereby inhibiting excitatory cytotoxicity (IC50 = 52.48 μM) and apoptosis (IC50 = 44.78 μM).[2] CALP1 (1 mg/kg) pretreatment prevents increases in lung alveolar inflammatory cells after six, but not 24, hours in sensitized guinea pigs challenged with ovalbumin in a model of allergic asthma.[3] It also decreases radical production induced by phorbol 12-myristate 13-acetatein broncho-alveolar lavage cells after six and 24 hours and dose-dependently decreases histamine-induced hyperresponsiveness in isolated guinea pig tracheal rings.

Reference:
[1]. Villain, M., Jackson, P.L., Manion, M.K., et al. De novo design of peptides targeted to the EF hands of calmodulin. J. Biol. Chem. 275(4), 2676-2685 (2000).
[2]. Manion, M.K., Su, Z., Villain, M., et al. A new type of Ca2+ channel blocker that targets Ca2+ sensors and prevents Ca2+-mediated apoptosis. FASEB J. 14(10), 1297-1306 (2000).
[3]. Ten Broeke, R., Brandhorst, M.C., Leusink-Muis, T., et al. Ca2+ sensors modulate asthmatic symptoms in an allergic model for asthma. Eur. J. Pharmacol. 476(1-2), 151-157 (2003).