您好，欢迎来到试剂仪器网！ [登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > DL-AP5
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
DL-AP5
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
DL-AP5图片
CAS NO:76326-31-3
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
DL-AP5 是一种 NMDA（N-甲基-D-天冬氨酸）受体拮抗剂。
Cas No.76326-31-3
别名DL-2-氨基-5-膦酰基缬草酸,DL-2-Amino-5-Phosphonovaleric acid，2-APV
化学名(R)-2-amino-5-phosphonopentanoic acid
Canonical SMILESOP(O)(CCC[C@H](C(O)=O)N)=O
分子式C5H12NO5P
分子量197.13
溶解度10mg/mL in PBS, pH 7.2
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DL-AP5 is the racemic version of the selective N-methyl-D-aspartate (NMDA) receptor antagonist, D-AP5.[1] Whereas D-AP5 is the active (–)-stereoisomer that competitively inhibits the glutamate binding site of NMDA receptors (Kd = 1.4 μM), the (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity.[1] AP5 has been widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory.[2]

Reference:
[1]. Evans, R.H., Francis, A.A., Jones, A.W., et al. The effects of a series of ω-phosphonic α-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br. J. Pharmacol. 75(1), 65-75 (1982).
[2]. Morris, R.J. Synaptic plasticity and learning: Selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5. J. Neurosci. 9(9), 3040-3057 (1989).