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MGR1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
MGR1图片
CAS NO:2361529-46-4
包装与价格：
包装价格(元)
500μg电议
1mg电议

产品介绍
 
Cas No.2361529-46-4
Canonical SMILESO=C1C2C(C3C=CC2CC3)C(C4=C(OCOC(C(C)(C)C)=O)C=CC=C41)=O
分子式C22H24O5
分子量368.4
溶解度DMF: 30 mg/mL,DMSO: 30 mg/mL,Ethanol: 30 mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

MGR1 is a probe that generates reactive oxygen species (ROS).1 Upon activation by esterases, MGR1 produces superoxide in vitro, an effect that is reversed by superoxide dismutase (SOD). MGR1 produces ROS and increases production of oxidized phosphatidylserine species in HEK293T cells. It reduces viability of HEK293T cells (IC50s = 5.1-6.3 μM).

References
1. Kelkar, D., Ravikumar, G., Mehendale, N., et al. A chemical-genetic screen identifies ABHD12 as an oxidized-phosphatidylserine lipase. Nat. Chem. Biol. 15(2), 169-178 (2019).