| CAS NO: | 154801-30-6 |
| 包装: | 1mg |
| 市场价: | 741元 |
| Cas No. | 154801-30-6 |
| Canonical SMILES | OC[C@H](NC([C@H](O)CCCCCCCCCCCCCCCCCCCCCC)=O)[C@@H]([C@@H](CCCCCCCCCCCCCC)O)O |
| 分子式 | C42H85NO5 |
| 分子量 | 684.1 |
| 溶解度 | Chloroform:Methanol (4:1): soluble,Ethanol: warmed |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | C24 (2'(R)-hydroxy) Phytoceramide is a naturally occurring sphingolipid that has been found in adlay seed hull.1 It inhibits LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages (IC50 = 19 μg/ml), as well as increases in COX-2 and inducible nitric oxide synthase (iNOS) levels. It increases production of chemokine (C-X-C motif) ligand 8 (CXCL8), CXCL1, chemokine (C-C motif) ligand 2 (CCL2), and CCL20 in human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner.2 C24 (2'(R)-hydroxy) Phytoceramide is a hydroxylated form of C24 phytoceramide . [Matreya, LLC. Catalog No. 2094] |1. Huang, D.-W., Chung, C.-P., Kuo, Y.-H., et al. Identification of compounds in adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) seed hull extracts that inhibit lipopolysaccharide-induced inflammation in RAW 264.7 macrophages. J. Agric. Food Chem. 57(22), 10651-10657 (2009).|2. Sekiya, M., Ueda, K., Okazaki, K., et al. A phytoceramide analog stimulates the production of chemokines through CREB activation in human endothelial cells. Int. Immunopharmacol. 11(10), 1497-1503 (2011). |
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