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Orexin 2 Receptor Agonist
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Orexin 2 Receptor Agonist图片
CAS NO:1796565-52-0
包装与价格：
包装价格(元)
2mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
Orexin 2 Receptor Agonist 是一种有效的（OX2R 上的 EC50 为 23 nM）和 OX2R 选择性（OX1R/OX2R EC50 比率为 70）激动剂。
Cas No.1796565-52-0
Canonical SMILESO=C(C1=CC=CC(C)=C1)NCCNC2=CC(NS(C3=C(OC)C=CC(C4=CC(C(N(C)C)=O)=CC=C4)=C3)(=O)=O)=CC=C2
分子式C32H34N4O5S
分子量586.7
溶解度DMSO : ≥ 32 mg/mL (54.54 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Orexin 2 Receptor Agonist is a potent (EC50 on OX2R is 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio is 70) agonist.IC50 value: 23 nM (EC50)Target: Orexin 2 ReceptorOrexin 2 Receptor Agonist shows not only potentactivity but also high selectivity for OX2R over OX1R. In CHO cells overexpressing hOX1R and HEK-293 cells overexpressing hOX2R, compound 26 displaced [125I]orexin-A in a concentration dependent manner: 26 bound to hOX2R and hOX1R with Ki of 0.14 and 0.77 uM, respectively.[1]

References:
[1]. Nagahara T, et al. Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists. J Med Chem. 2015 Oct 22;58(20):7931-7.