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KRN2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KRN2图片
CAS NO:248260-75-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
KRN2 是选择性的 T 细胞激活核因子 (NFAT5) 的抑制剂,IC50值为 100 nM。KRN2 有潜力用于 NFAT5-介导的慢性关节炎的潜能。
生物活性

KRN2 is a selective inhibitor ofnuclear factor of activated T cells(NFAT5), with anIC50of 100 nM. KRN2 has potential to treat NFAT5-mediated Chronic Arthritis[1].

IC50& Target

IC50: 100 nM (NFAT5)[1].

体外研究
(In Vitro)

KRN2 selectively suppresses the expression of pro-inflammatory genes, including Nos2 and Il6, without hampering high-salt-induced NFAT5 and its target gene expressions[1].
KRN2 dose-dependently inhibits the NF-κB p65 binding to Nfat5 promoter 1 and directly blocks the interaction between NF-κB p65 and its DNA binding sequence in the upstream site (base pairs -3000 to +1) ofNfat5exon 1[1].

体内研究
(In Vivo)

KRN2 (3 mg/kg, i.p., daily for 2 weeks) effectively suppresses AIA in which innate immune cells play a predominant role[1].
KRN2 (3 mg/kg, i.p., daily) effectively suppresses CIA as well as AIA in mice, decreasing the production of pro-inflammatory cytokines and autoantibodies as well as macrophage infiltration[1].

Animal Model:8-week-old C57BL/6 mice injected intradermally with 2 mg of complete Freund's adjuvant[1].
Dosage:3 mg/kg.
Administration:Peritoneally (i.p.) daily for 2 weeks.
Result:Effective in suppressing AIA.
Animal Model:8-week-old DBA/1Jmice immunized with bovine type II collagen[1].
Dosage:3 mg/kg.
Administration:Peritoneally (i.p.) daily.
Result:Effective in suppressing CIA as well as AIA in mice, decreasing the production of pro-inflammatory cytokines and autoantibodies as well as macrophage infiltration.
分子量

479.93

Formula

C27H23ClFNO4

CAS 号

248260-75-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.