CAS NO: | 132819-92-2 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors,NOD1andNOD2, withIC50of 5.74 μM and 6.45 μM, respectively. | ||||||||||||||||
IC50& Target | IC50: 5.74 μM (NOD1), 6.45 μM (NOD2)[1] | ||||||||||||||||
体外研究 (In Vitro) | NOD-IN-1 (compound 4) is potent mixed inhibitor of NOD1 and NOD2, displaying a balanced inhibitory activity on both targets in the low micromolar range. NOD-IN-1 (IC50(NOD1)=5.74 μM; IC50(NOD2)=6.45 μM) is identified as the best of the series, possessing NOD1- and NOD2-inhibitory activities in the lower micromolar range. These results show that NOD-IN-1 is 7-fold less potent than Noditinib-1 in terms of NOD1 inhibition and completely devoid of selective activity for NOD1 or NOD2 as opposed to Noditinib-1. NOD-IN-1 exhibits balanced dual activities of less than 10 μM on the two targets[1]. | ||||||||||||||||
分子量 | 343.40 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C18H17NO4S | ||||||||||||||||
CAS 号 | 132819-92-2 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(291.21 mM;Need ultrasonic) 配制储备液
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