CAS NO: | 53774-63-3 |
包装 | 价格(元) |
10 mM * 1 mL in Water | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | L-NIL is aninducibleNO synthaseinhibitor, with anIC50of 3.3 μM for miNOS[1][2][3]. | ||||||||||||||||
IC50& Target | IC50: 3.3 μM (mouse inducible NO synthase), 92 μM (rat brain constitutive NO synthase)[1] | ||||||||||||||||
体外研究 (In Vitro) | L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS (miNOS) and the rat brain constitutive NOS (rcNOS) and is considerably more potent for miNOS. The IC50values for L-NIL with miNOS and rcNOS are 3.3 and 92 pM, respectively, indicating that L-NIL is 28-fold more selective for miNOS. In addition, L-NIL has approximately 6-fold greater potency for miNOS than either L-NMA or L-NNA[3]. | ||||||||||||||||
体内研究 (In Vivo) | L-NIL (10 and 30 mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice[1].
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分子量 | 187.24 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C8H17N3O2 | ||||||||||||||||
CAS 号 | 53774-63-3 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : 50 mg/mL(267.04 mM;Need ultrasonic) DMSO :< 1 mg/mL(insoluble or slightly soluble) 配制储备液
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