Levocabastine (R 50547) hydrochloride 是一种有效的选择性组胺 H1 受体拮抗剂。
| Cas No. | 79547-78-7 |
| 别名 | R 50547 hydrochloride |
| Canonical SMILES | FC(C=C1)=CC=C1[C@@](CC2)(C#N)CC[C@@H]2N(C[C@H]3C)CC[C@]3(C(O)=O)C4=CC=CC=C4.Cl |
| 分子式 | C26H29FN2O2• HCl |
| 分子量 | 457 |
| 溶解度 | PBS (pH 7.2): 0.33 mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Levocabastine is a potent and selective histamine H1 receptor antagonist with an IC50 value of 8.32 nM (Kis = 62.5, 23,500, and 1,937 nM for H1, H2, and H3, respectively) for inhibition of phosphoinositide turnover on human conjunctival epithelial cells. It has been used in clinical formulations in eye drops and nasal sprays for the treatment of allergic conjunctivitis and allergic rhinitis, respectively. Levocabastine also binds with high affinity to the rat neurotensin-2 receptor with an IC50 value of 10 nM. |
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