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Mavoglurant racemate(AFQ-056 racemate)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Mavoglurant racemate(AFQ-056 racemate)图片
CAS NO:1636881-61-2
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
2mg电议
5mg电议

产品介绍
Mavoglurant 外消旋体 (AFQ-056 racemate) (AFQ-056 racemate) 是 Mavoglurant 的外消旋体。
Cas No.1636881-61-2
别名AFQ-056 racemate
Canonical SMILESCC1=CC(C#C[C@]2(O)CCC[C@]3([H])[C@@]2([H])CCN3C(OC)=O)=CC=C1.[relative stereochemistry]
分子式C19H23NO3
分子量313.39
溶解度DMSO : 50 mg/mL (159.55 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Mavoglurant (racemate) is the racemate of mavoglurant. Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist.

For antagonistic activity, (-)-mavoglurant, the (-)-enantiomer shows IC50 of 0.11 μM and 0.03 μM (Ca2+ and PI-turnover) whereas the (+)-enantiomer ((+)-10) shows only 37% and 18% inhibition at 10 μM[1].

[1]. Vranesic I, et al. AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: identification, SAR and pharmacological characterization. Bioorg Med Chem. 2014 Nov 1;22(21):5790-803