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MS049 2HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MS049 2HCl图片
CAS NO:2095432-59-8
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)321.29
FormulaC15H26Cl2N2O
CAS No.1502816-23-0(free base)
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 56 mg/mL (174.3 mM)
Water: 56 mg/mL (174.3 mM)
Ethanol: 50 mg/mL (155.6 mM)
Other info

Chemical Name: [2-(4-Benzyloxy-piperidin-1-yl)-ethyl]-methyl-amine

InChi Key: HBOJWAYLSJLULG-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H24N2O/c1-16-9-12-17-10-7-15(8-11-17)18-13-14-5-3-2-4-6-14/h2-6,15-16H,7-13H2,1H3

SMILES Code: CNCCN1CCC(OCC2=CC=CC=C2)CC1

Synonyms

MS049 diHCl; MS-049; MS 049.

实验参考方法
In Vitro

In vitro activity: MS049 does not inhibit any of the methyltransferases at 50 μM or demethylases at 10 μM and does not display appreciable binding to any of the methyllysine/methylarginine reader proteins using the DSF assay at 200 μM. MS049 demonstrated excellent selectivity over a broad range of epigenetic and nonepigenetic targets. In cellular assays, MS049 potently inhibits the methyltransferase activity of PRMT4 and PRMT6 and reduces levels of Med12me2a and H3R2me2a in HEK293 cells.


Cell Assay: MS 049 reduces the H3R2me2a mark in HEK293 cells in a concentration dependent manner. MS 049 treatment (72 h exposure) inhibits endogenous PRMT4 methyltransferase activity in a concentration dependent manner resulting in reduced levels of cellular asymmetric arginine dimethylation of Med12 (Med12-Rme2a, IC50 = 1.4 ± 0.1 μM (n = 3)) in HEK293 cells.

In Vivo
Animal model
Formulation & Dosage
References

J Med Chem. 2016 Oct 13;59(19):9124-9139.