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Chitosan(Deacetylated chitin)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Chitosan(Deacetylated chitin)图片
CAS NO:9012-76-4
包装:10g
市场价:446元

产品介绍
壳聚糖(脱乙酰壳多糖)(脱乙酰壳多糖)是一种衍生自壳多糖的聚阳离子线性多糖。
Cas No.9012-76-4
别名壳聚糖,Deacetylated chitin (MW 150000); Poly(D-glucosamine) (MW 150000)
Canonical SMILESO[C@H]1[C@H](O)[C@@H](N)[C@H](O[C@H]2[C@H](O)[C@@H](N)[C@H](O[C@H]3[C@H](O)[C@@H](N)[C@H](O)O[C@@H]3CO)O[C@@H]2CO)O[C@@H]1CO.[n]
分子式(C6H13NO5)n
分子量161.16(monomer)
溶解度Water : 0.67 mg/mL (ultrasonic and adjust pH to 3 with HCl);Water :< 0.1 mg/mL (insoluble);DMSO :< 1 mg/mL (insoluble or slightly soluble)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Chitosan is a natural polycationic linear polysaccharide derived from chitin.

Chitosans are recognized as versatile biomaterials because of their non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan is reported to have other biological properties, such as antitumor, antimicrobial, and antioxidant activities. It can be used in water treatment, wound-healing materials, pharmaceutical excipient or drug carrier, obesity treatment and as a scaffold for tissue engineering[1]. Antimicrobial activity of chitosan has been demonstrated against many bacteria, filamentous fungi and yeasts. Chitosan has wide spectrum of activity and high killing rate against Gram-positive and Gram-negative bacteria, but lower toxicity toward mammalian cells[2]. Chitosan exhibits antitumor activity against different types of cancer. For example, chitosan decreases adhesion of primary melanoma A375 cell line and decreases proliferation of primary melanoma SKMEL28 cell line, it has potent pro-apoptotic effects against RPMI7951, a metastatic melanoma cell line[3]. Chitosan and its derivatives act as antioxidants by scavenging oxygen radicals such as hydroxyl, superoxide, alkyl as well as highly stable DPPH radicals in vitro[4].

Chitosan treatment dramatically increases lifespan and inhibits tumor metastasis especially in treatment groups of the low-molecular weight compound[5]. Chitosan has some apparent treatment effects on rat PCP by reducing HSP70 mRNA expression and lung inflammation, increasing the concentrations of IL-10 and IFN-γ as well as CD4(+) T-lymphocyte numbers, reducing the CD8(+) T-lymphocyte numbers and the concentration of TNF-α and inducing significant ultrastructural damage to P. carinii[6].

[1]. Cheung RC, et al. Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications. Mar Drugs. 2015 Aug 14;13(8):5156-86. [2]. Kong M, et al. Antimicrobial properties of chitosan and mode of action: a state of the art review. Int J Food Microbiol. 2010 Nov 15;144(1):51-63. [3]. Gibot L, et al. Anticancer properties of chitosan on human melanoma are cell line dependent.Int J Biol Macromol. 2015 Jan;72:370-9. [4]. Younes I, et al. Chitin and chitosan preparation from marine sources. Structure, properties and applications. Mar Drugs. 2015 Mar 2;13(3):1133-74. [5]. Yeh MY, et al. Effects of chitosan on xenograft models of melanoma in C57BL/6 mice and hepatoma formation in SCID mice. Anticancer Res. 2013 Nov;33(11):4867-73. [6]. Liu AB, et al. Therapeutic efficacies of chitosan against Pneumocystis pneumonia of immunosuppressed rat. Parasite Immunol. 2014 Jul;36(7):292-302