BTZO-1 binds toMacrophage migration inhibitory factor (MIF)with aK_dvalue of 68.6 nM, and its binding requires the N-terminal Pro1. BTZO-1 can activate antioxidant response element (ARE)-mediated gene expression and suppress oxidative stress-induced cardiomyocyteapoptosisin vitro^[1].

Kd:68.6 nM (Macrophage migration inhibitory factor)^[1]

BTZO-1 (0-330 nM; 24 hours) dose-dependently suppressed serum deprivation-induced cardiomyocyte death; the minimum effective concentration (MEC1.5), the concentration of a sample necessary to give a 50% increase in cell viability, is 16 nM^[1].
BTZO-1 (0.37 μM; 21 hours) upregulates mRNA protein levels of GST Ya and HO-1 in cardiomyocytes^[1].

240.28

Solid

C₁₃H₈N₂OS

99420-15-2

Room temperature in continental US; may vary elsewhere.

DMSO : 8.33 mg/mL(34.67 mM;Need ultrasonic)

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