MD13

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MD13

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2758431-97-7

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

MD13 是一种巨噬细胞迁移抑制因子 (MIF) 导向的PROTAC，K_i值为 71 nM。MD13 可用于癌症研究。

生物活性

MD13 is amacrophage migration inhibitory factor(MIF)-directedPROTACwith aK_iof 71 nM. MD13 can be used forcancerresearch^[1].

IC₅₀& Target

K_i: 71 nM (MIF)^[1]

体外研究
(In Vitro)

MD13 degrades 91±5% and 71±7% MIF at 2 μM and 0.2 μM, respectively. MD13 induces MIF degradation through binding to E3 ligase cereblon^[1].
MD13 (0-20 μM; 72 h) inhibits cell proliferation of A549 cancer cells^[1].
MD13 (1-5 μM; 48 h) arrests cell cycle at G2/M phase in A549 cells^[1].
MD13 (2 μM; 6-48 h) inhibits ERK signaling^[1].

Western Blot Analysis^[1]

Cell Line:	A549 cells
Concentration:	0-20 μM
Incubation Time:	12 h
Result:	Caused depletion of MIF protein.

Western Blot Analysis^[1]

Cell Line:	A549 cells
Concentration:	2 μM
Incubation Time:	6, 24 or 48 h
Result:	Inhibited ERK phosphorylation.

Cell Proliferation Assay^[1]

Cell Line:	A549 cells
Concentration:	0-20 μM
Incubation Time:	72 h
Result:	Inhibited the growth of A549 cells in a dose-dependent manner. The inhibitory effect reached about 50% inhibition of cell proliferation at a concentration of 20 μM.

Cell Cycle Analysis^[1]

Cell Line:	A549 cells
Concentration:	1, 2, or 5 μM
Incubation Time:	48 h
Result:	Dose-dependently induced cell cycle arrest at the G2/M phase.

分子量

653.68

Formula

C₃₅H₃₅N₅O₈

CAS 号

2758431-97-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.