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SR 49059
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SR 49059图片
CAS NO:150375-75-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议

产品介绍
SR 49059 (SR-49059) 是一种有效的、具有口服活性的、选择性的vasopressin V1a拮抗剂,Ki值为 1.4 nM.
生物活性

SR 49059 (SR-49059) is a potent, orally active, selectivevasopressin V1aantagonist with aKivaule of 1.4 nM[1].

IC50& Target

Ki: 1.4±0.3 nM (vasopressin V1a)[1].

体内研究
(In Vivo)

SR 49059 (SR-49059) (2 mg/kg and 30 mg/kg; i.p.; once) shows neuroprotective effects in ischemic brain injury when injected early after occlusion of the middle cerebral artery (MCA)[2].

Animal Model:Male Wistar rats, weighing 300 to 350 g, cerebral focal ischemia model[2]
Dosage:2 mg/kg and 30 mg/kg dissolved in 10% dimethyl sulfoxide
Administration:Intraperitoneal injection, once
Result:Significantly reduced infarction volume measured at 48 hours after the arterial occlusion. Reduced neurological deficits and ischemic brain edema.
分子量

620.50

性状

Solid

Formula

C28H27Cl2N3O7S

CAS 号

150375-75-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
In solvent-80°C6 months
-20°C1 month