Teprotumumab

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Teprotumumab

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1036734-93-6

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议

产品介绍

Teprotumumab 是一种阻断IGF-1受体 (IGF-1R) 的人单克隆抗体。Teprotumumab 与 IGF-1R 的细胞外 α-亚基结构域配体结合。Teprotumumab 抑制纤维细胞中的TSH和 IGF-1 作用。Teprotumumab 可降低 TSH 依赖性 IL-6 和 IL-8 的表达和 Akt 的磷酸化。Teprotumumab 可用于甲状腺相关眼病的研究。

生物活性

Teprotumumab is anIGF-1 receptor (IGF-1R)blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain ofIGF-1R. Teprotumumab inhibitsTSHand IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependentIL-6andIL-8expression andAktphosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research^[1].

体外研究
(In Vitro)

Teprotumumab (0-500 μg/mL, 12 h) attenuates the actions of both IGF-1 and TSH in fibrocytes. IGF-1R and TSHR mRNA abundance is unaffected by Teprotumumab after 24 hours^[1].

Clinical Trial

性状

Liquid

CAS 号

1036734-93-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.