Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) withEC₅₀s of 0.2 and 7.7 μM, respectively.

EC50: 0.2 μM (LHCGR), 7.7 μM (TSHR)^[1]

Functional assays demonstrate that Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC₅₀s of 0.2 and 7.7 μM, respectively. Treatment of L570F with Org41841 reveals an improved EC₅₀of 800 nM. M9 responds to Org41841 with an improved EC₅₀of 2700 nM and a greatly improved efficacy for signaling to 99% of the maximal value observed for thyroid-stimulating hormone (TSH) stimulation of thyroid-stimulating hormone receptor (TSHR)^[1].

402.53

Solid

C₁₉H₂₂N₄O₂S₂

301847-37-0

Room temperature in continental US; may vary elsewhere.

DMSO : 100 mg/mL(248.43 mM;Need ultrasonic)

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