cis-Epoxysuccinic acid

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CAS NO:

16533-72-5

包装与价格：

包装	价格(元)
100mg	电议
500mg	电议
1 g	电议
5 g	电议

产品介绍

cis-Epoxysuccinic acid 是succinate receptor (SUCNR1/GPR91)的激动剂。cis-Epoxysuccinic acid 抑制 cAMP 的水平，其EC₅₀值为 2.7 μM。cis-Epoxysuccinic acid 可用于心血管系统的研究。

生物活性

cis-Epoxysuccinic acid is asuccinate receptor(SUCNR1/GPR91)agonist. cis-Epoxysuccinic acid inhibits cAMP levels with anEC₅₀value of 2.7 μM. cis-Epoxysuccinic acid can be used for the research of cardiovascular system^[1].

体外研究
(In Vitro)

cis-Epoxysuccinic acid (1-100 μM; 10 min) affects cAMP levels of HEK293 cells^[1].
cis-Epoxysuccinic acid (0.1 μM-100 mM; 1 h) agonists SUCNR1 pathways without affects succinate dehydrogenase^[1].

Cell Viability Assay^[1]

Cell Line:	HEK293 cells
Concentration:	1, 10 and 100 μM
Incubation Time:	10 min
Result:	Inhibited cAMP levels with an EC₅₀value of 2.7 μM.

Cell Viability Assay^[1]

Cell Line:	HEK293 cells
Concentration:	0.1 μM-100 mM
Incubation Time:	1 hour
Result:	Induced the Gq pathway, recruited arrestin 3 and elicited [Ca²⁺]_imobilization with EC₅₀values of 42, 74 and 191 μM, respectively.

体内研究
(In Vivo)

cis-Epoxysuccinic acid (1 mg/kg; i.v. once) has an effect on the blood pressure of rats^[1].

Animal Model:	Male Wistar rats^[1]
Dosage:	1 mg/kg
Administration:	Intravenous injection; 1 mg/kg once
Result:	Showed in vivo activity and increased blood pressure after injection.

分子量

132.07

性状

Solid

Formula

C₄H₄O₅

CAS 号

16533-72-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : ≥ 250 mg/mL(1892.94 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	7.5717 mL	37.8587 mL	75.7174 mL
5 mM	1.5143 mL	7.5717 mL	15.1435 mL
10 mM	0.7572 mL	3.7859 mL	7.5717 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。