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N-octanoyl-L-Homoserine lactone
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
N-octanoyl-L-Homoserine lactone图片
CAS NO:147852-84-4
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
N-辛酰基-L-高丝氨酸内酯是一种小的可扩散信号分子，参与群体感应，从而控制基因表达并影响细胞代谢。
Cas No.147852-84-4
别名辛酰基-L-高丝氨酸内酯,C8-HSL,OHL
化学名N-[(3S)-tetrahydro-2-oxo-3-furanyl]-octanamide
Canonical SMILESCCCCCCCC(=O)C[C@H]1CCOC1=O
分子式C12H21NO3
分子量227.3
溶解度DMF: 25 mg/ml,DMF:PBS(pH7.2) 1:2: 0.3 mg/ml,DMSO: 20 mg/ml,Ethanol: 10 mg/ml
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by synthesis of diffusible acylhomoserine lactone (AHL) molecules. N-

octanoyl-L-Homoserine lactone (C8-HSL) is a small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism.1,2,3The applications of this molecule include infection prevention and regulation of virulence in general and in cystic fibrosis.4,5

References
1. Kuo, A., Blough, N.V., and Dunlap, P.V. Multiple N-acyl-L-homoserine lactone autoinducers of luminescence in the marine symbiotic bacterium Vibrio fischeri Journal of Bacteriology 176(24), 7558-7565 (1994).
2. Lithgow, J.K., Wilkinson, A., Hardman, A., et al. The regulatory locus cinRI in Rhizobium leguminosarum controls a network of quorum-sensing loci Molecular Microbiology 37(1), 81-97 (2000).
3. McClean, K.H., Winson, M.K., Fish, L., et al. Quorum-sensing and Chromobacterium violaceum: Exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones Microbiology 143, 3703-3711 (1997).
4. Riedel, K., Hentzer, M., Geisenberger, O., et al. N-acylhomoserine-lactone-mediated communication between Pseudomonas aeruginosa and Burkholderia cepacia in mixed biofilms Microbiology 147, 3249-3262 (2001).
5. Winson, M.K., Camara, M., Latifi, A., et al. Multiple N-acyl-L-homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa Proceedings of the National Academy of Sciences of the United States of America 92, 9427-9431 (1995).