Cortistatin 29 是一种神经肽。Cortistatin 29 可减轻神经性疼痛。Cortistatin 29 以高亲和力结合所有生长抑素 (SS) 受体亚型，对 SSTR1、SSTR2、SSTR3、 SSTR4，SSTR5 的< b>IC50值分别为 2.8,7.1,0.2,3.0,13.7 nM。Cortistatin 29 显示出抗纤维化作用。
| 生物活性 | Cortistatin 29 is a neuropeptide. Cortistatin 29 alleviates neuropathic pain. Cortistatin 29 binds with high affinity all somatostatin (SS) receptor subtypes and showsIC50values of 2.8, 7.1, 0.2, 3.0, 13.7 nM forSSTR1,SSTR2,SSTR3,SSTR4,SSTR5, respectively. Cortistatin 29 shows anti-fibrotic effects[1][2][3][4]. |
| IC50& Target[3] | SSTR1 2.8 nM (IC50) | SSTR2 7.1 nM (IC50) | SSTR3 0.2 nM (IC50) | SSTR4 3.0 nM (IC50) | SSTR5 13.7 nM (IC50) |
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体内研究
(In Vivo) | Cortistatin 29 (1-2 μg) alleviates chronic neuropathic pain in mouse[1].
Cortistatin 29 (1 nmol/mouse; i.p.; three times weekly) shows anti-fibrotic effects in mouse[4].
| Animal Model: | 20-24 g body weight, 8-12 weeks-old mice[1] | | Dosage: | 1 μg in 20 μL for s.c.; 2 μg in 200 μL for i.p.; 20 ng in 10 μL for i.t. | | Administration: | Every other day for 12 days | | Result: | Ameliorated hyperalgesia and allodynia, regulated the nerve damageinduced hypersensitization of primary nociceptors, inhibited neuroinflammatory responses, and enhanced the production of neurotrophic factors both at the peripheral and central levels. |
| Animal Model: | 20-24g body weight, 8-10 weeks-old C57BL/6 mice (CST+/+, CST+/- and CST-/- mice)[4]. | | Dosage: | 1 nmol/mouse | | Administration: | I.p., three times weekly from 5 or 14 days | | Result: | Reversed in vivo and in vitro these exaggerated fibrogenic phenotypes and protected from progression to severe liver fibrosis in response to hepatic injury. |
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| 分子量 | |
| Formula | |
| Sequence Shortening | {Glp}-ERPPLQQPPHRDKKPCKNFFWKTFSSCK |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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