Oxyphenbutazone 是一种 Phenylbutazone 代谢物，具有抗炎作用。
| Cas No. | 129-20-4 |
| 别名 | 羟布宗 |
| Canonical SMILES | O=C(C1CCCC)N(C2=CC=CC=C2)N(C3=CC=C(O)C=C3)C1=O |
| 分子式 | C19H20N2O3 |
| 分子量 | 324.4 |
| 溶解度 | DMF: 25 mg/ml,DMSO: 25 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 0.5 m/ml,Water: 1 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Oxyphenbutazone is a metabolite of phenylbutazone . Both compounds were identified as having anti-inflammatory effects in early studies, and, as a result, are considered NSAIDs. Interestingly, the effects of the two compounds in animal models differ, with phenylbutazone having anti-inflammatory effects in rheumatic diseases and oxyphenbutazone reducing edema in certain types of acute inflammation. Oxyphenbutazone is a poor inhibitor of prostaglandin synthesis, but, like other NSAIDs, it inhibits organic anion transporter 1 (Ki = 32 µM). It inhibits the growth of MH60/BSF-2 cells induced by IL-6 (IC50 = 7.5 µM). Oxyphenbutazone stimulates neurite outgrowth at 1.5 µM and sensitizes M. tuberculosis to antimicrobials. |
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