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(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin图片
CAS NO:114056-26-7
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin 是催产素 (oxytocin) 拮抗剂，可用于性行为的研究。
生物活性

(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin is anoxytocinantagonist and can be used for the research of sexual behavior[1].

IC50& Target

Oxytocin[1]

体内研究
(In Vivo)

(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin (50-1000 ng; Intra-MPOA; 1 μL) 抑制大鼠雄性性行为的某些方面[1]。
(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin (100 ng; i.c.v.; 1 μL) 可有效抑制雄性大鼠交配行为后的痛觉减退[2]。

Animal Model:Adult Long–Evans/Blue-Spruce rats[1]
Dosage:50 ng, 200 ng, and 1 μg
Administration:Intra-MPOA (medial preoptic area) injection, 1 μL
Result:Significantly increased intromission latency and anogenital investigation at 1 μg dose. Significantly decreased intromission ratio (2) at all doses.
Animal Model:Adult male and female Long-Evans rats (8 weeks old, 220–260 g BW)[2]
Dosage:100 ng
Administration:Intracerebroventricular injection, 1 μL
Result:Was effective in reducing pain threshold heightened by copulatory behavior.
分子量

1154.40

Formula

C54H79N11O13S2

CAS 号

114056-26-7

Sequence Shortening

XYITNC(Unk)PXY(Me)-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

 ContentsAssign value
Acidic amino acidAsp (D), Glu (E), and the C-terminal -COOH.-1
Basic amino acidArg (R), Lys (K), His (H), and the N-terminal -NH2+1
Neutral amino acidGly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)0

3.  Recommended solution:

Overall charge of peptideDetails
Negative (<0)1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.