Barusiban

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Barusiban

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

285571-64-4

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

FE-200440

产品介绍

Barusiban (FE-200440) 是一种催产素受体 (OT-R) 拮抗剂 (K_i=0.8 nM)，可抑制 OT 引起的收缩。Barusiban 可用于早产 (PTL)、体外受精 (IVF) 和不孕症的研究。

生物活性

Barusiban (FE-200440) is anoxytocin receptor(OT-R) antagonist (K_i=0.8 nM), inhibits OT-induced contraction. Barusiban can be used in preterm labor (PTL), in vitro fertilisation (IVF) and infertility research^[1]^[2]^[3].

体外研究
(In Vitro)

Barusiban shows affinity for oxytocin receptor (K_i=0.8 nM) in COS cells expressed with oxytocin receptor^[3].

体内研究
(In Vivo)

Barusiban (intravenous injection; 50 or 150 μg/kg; once) treatment shows inhibition on OT-induced contractions^[2].

Animal Model:	Pregnant cynomolgus monkeys injected with oxytocin (OT)^[2]
Dosage:	50 or 150 μg/kg
Administration:	Intravenous injection; 50 or 150 μg/kg; once
Result:	Reduced uterine contractions to baseline levels effectively. Reduced intrauterine pressure (IUP) from 6-7.5 kmm Hgoh to approximately 1 kmm Hgoh.

Clinical Trial

分子量

830.05

Formula

C₄₀H₆₃N₉O₈S

CAS 号

285571-64-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.