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(Thr4,Gly7)-Oxytocin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(Thr4,Gly7)-Oxytocin图片
CAS NO:60786-59-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
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产品介绍
(Thr4,Gly7)-Oxytocin, 一种催产素 (Oxytocin) 类似物,是一种特异性OT 受体激动剂。(Thr4,Gly7)-Oxytocin 还可通过激活 TRPV1 通道和抑制 K+通道来诱导眼下神经元兴奋。
生物活性

(Thr4,Gly7)-Oxytocin, an Oxytocin analogue, is a specificOT receptoragonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K+channels.[1][2].

IC50& Target

OT receptors, K+channels[1].

体外研究
(In Vitro)

(Thr4,Gly7)-Oxytocin (1 μM, 1 min) evokes an inward current of 5.9 pA in paraventricular thalamus (PVT) neurons[1].
(Thr4,Gly7)-Oxytocin (1 μM, 1 min) increases spontaneous excitatory postsynaptic currents (sEPSCs) frequency in PVT neurons[1].
(Thr4,Gly7)-Oxytocin (0.3 μM, 5 min) induces depolarization in both bursting cells and regular firing cells[2].
(Thr4,Gly7)-Oxytocin (0.3 μM, 5 min) depolarizes subicular neurons by activating TRPV1 channels[2].

体内研究
(In Vivo)

(Thr4,Gly7)-Oxytocin (1 μM, direct intra-PVT infusion for 1 min) evokes depolarization on TGOT-responsive neurons in mice[1].
(Thr4,Gly7)-Oxytocin (100 ng, intracerebroventrical injection) increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats[3].

Animal Model:Swiss Webster mice[1]
Dosage:1 μM
Administration:Intratracheal administration for 24 h
Result:Excited 34.3% of aPVT neurons, 57.6% of mPVT neurons, and 60.0% of pPVT neurons.
Increased the firing rate of TGOT-responsive PVT neurons in all subregions.
分子量

940.10

性状

Solid

Formula

C39H61N11O12S2

CAS 号

60786-59-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

H2O : 100 mg/mL(106.37 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.0637 mL5.3186 mL10.6372 mL
5 mM0.2127 mL1.0637 mL2.1274 mL
10 mM0.1064 mL0.5319 mL1.0637 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。