Hypocretin(70-98),human

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CAS NO:

1129545-33-0

包装与价格：

产品介绍

Hypocretin (70-98), human 是一种多肽，能够与食欲素受体OX1R结合，促进凋亡 (apoptosis)。

生物活性

Hypocretin (70-98), human is a polypeptide that is capable of binding to anorexin receptorOX1Rand promotesapoptosis^[1].

IC₅₀& Target^[1]

human OX1R

体外研究
(In Vitro)

Hypocretin (70-98), human 促进表达食欲素受体的细胞凋亡。 OX1R 促进癌细胞凋亡的机制与 Gq 介导的磷脂酶 C 激活和细胞钙瞬变无关。

分子量

2957.37

Formula

C₁₂₅H₂₁₄N₄₄O₃₇S

CAS 号

1129545-33-0

Sequence Shortening

RSGPPGLQGRLQRLLQASGNHAAGILTMG

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.