Tyr-Gly-Gly-Phe-Met-OH

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

58569-55-4

包装与价格：

包装	价格(元)
10 mM * 1 mL in Water	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品名称

蛋氨酸脑啡肽
Met-Enkephalin
Methionine enkephalin

产品介绍

Tyr-Gly-Gly-Phe-Met-OH 通过结合阿片样物质受体(opioid receptor)，可调控人类免疫功能，抑制肿瘤生长。

生物活性

Tyr-Gly-Gly-Phe-Met-OH regulates human immune function and inhibits tumor growth via binding to theopioid receptor.

IC₅₀& Target

Opioid Receptor^[1].

体外研究
(In Vitro)

Methionine enkephalin (MENK), an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems. MENK is believed to have an immunoregulatory activity to have cancer biotherapy activity by binding to the opioid receptors on immune and cancer cells. MENK may also change the tumor microenvironment by binding to opioid receptor on or in cancer cells. All of these mechanisms of action have biologic significance and potential for use in cancer immunotherapy. Furthermore, they reveal a relationship between the endocrine and immune systems^[1].

分子量

573.66

性状

Solid

Formula

C₂₇H₃₅N₅O₇S

CAS 号

58569-55-4

Sequence

Tyr-Gly-Gly-Phe-Met

Sequence Shortening

YGGFM

中文名称

蛋氨酸脑啡肽

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO : ≥ 40 mg/mL(69.73 mM)

H₂O : 6.67 mg/mL(11.63 mM;Need ultrasonic)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.7432 mL	8.7160 mL	17.4319 mL
5 mM	0.3486 mL	1.7432 mL	3.4864 mL
10 mM	0.1743 mL	0.8716 mL	1.7432 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。