5'-Guanidinonaltrindole (5'-GNTI) hydrochloride is a highly selective and potentκ-opioid receptorantagonist with aK_iof 0.18 nM for human κ-opioid receptor^[1].

5'-Guanidinonaltrindole (5'-GNTI) also binds to human μ- and δ-opioid receptors with K_is of 36.9±2.3 nM and 70.0±0.3 nM, respectively^[1].
5'-Guanidinonaltrindole is most effective at κ-opioid receptors (pA₂=10.4±0.10), with substantially lower antagonist potency at μ-opioid (pA₂=8.49±0.09) and δ-opioid receptors (pA₂=7.81±0.06)^[1].

5'-Guanidinonaltrindole (5'-GNTI) (0.03-3 mg/kg; s.c.; once) induces scratching in mice^[2].

544.47

Solid

C₂₇H₃₁Cl₂N₅O₃

351183-88-5

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

DMSO : 125 mg/mL(229.58 mM;ultrasonic and warming and heat to 60℃)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。