RFRP-3 (Neuropeptide VF(124-131))(human), a humanGnIH peptidehomolog, is a potent inhibitor ofgonadotropin secretionby inhibiting Ca²⁺ mobilization. RFRP-3(human) is aNPFF1 receptoragonist, it inhibits forskolin-induced production of cAMP with an IC₅₀of 0.7 nM^[1].

RFRP-3 efficiently inhibits forskolin-induced production of cAMP with an IC₅₀of 0.7 nM^[1].
Scatchard-plot analysis shows that¹²⁵I-labelled hRFRP-3 has a single class of high-affinity binding sites for the membrane fractions of CHO cells expressing rat OT7T022, the K_dvalue and the B_maxvalues are 0.19 nM and 1.3 pM, respectively.
RFRP-3 specifically stimulate cells transfected with a new orphan 7TMR, OT7T022, it binds to OT7T022 as a specific ligand with high affinity (K_d= 0.19 nM)^[1].
RFRP-3 (10^-8 to 10^-14M) has no effect on LH and FSH levels alone, but when it combines with GnRH, LH and FSH secretion is significantly reduced by the combination^[1].

969.14

Solid

C₄₅H₇₂N₁₄O₁₀

311309-27-0

VPNLPQRF-NH2

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

DMSO : ≥ 100 mg/mL(103.18 mM)

*"≥" means soluble, but saturation unknown.

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。