(Pro34)-Peptide YY(human)

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

179986-93-7

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

(Pro34)-Peptide YY (human) 是 Peptide YY (HY-P1514)/neuropeptide Y 受体的高度Y₁选择性全激动剂。

生物活性

(Pro34)-Peptide YY (human) is a highlyY₁-selective full agonist ofPeptide YY(HY-P1514)/neuropeptide Y receptors^[1].

IC₅₀& Target^[1]

NPY Y₁receptor

体外研究
(In Vitro)

(Pro34)-Peptide YY (human) 在完整的 SK-N-MC 和 HEL 细胞 (Y₁样亚型) 和猪脾膜 (Y₂样亚型) 中竞争所有特定的 [¹²⁵I] 神经肽 Y 结合位点。(Pro34)-Peptide YY 在完整的 SK-N-MC 和 HEL 细胞中的亲和力 (pK_i分别为 7.8 ± 0.2 和 8.2 ± 0.1) 与 Peptide YY (pK_i分别为 8.5 ± 0.1 和 8.6 ± 0.1) 非常相似^[1]。

分子量

4278.73

Formula

C₁₉₄H₂₉₄N₅₄O₅₆

CAS 号

179986-93-7

Sequence Shortening

YPIKPEAPGEDASPEELNRYYASLRHYLNLVTRPRY-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.