Motilin (26-47), human, porcine is an endogenousmotilin receptorligand withK_iandEC₅₀of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line.

EC50: 0.3 nM (motilin receptor, Chinese hamster ovary cell)^[1]
Ki: 2.3 nM (motilin receptor, Chinese hamster ovary cell)^[1]

[Bpa¹,Ile¹³]motilin is a full agonist at the motilin receptor that increases intracellular calcium in a concentration-dependent manner (EC₅₀= 1.5 ± 0.4 nM)^[1]. Motilin binds with high affinity (IC₅₀0.7± 0.2 nM) to receptors on smooth muscle cells. Motilin selectively activates G(q) and G(13), stimulates G alpha(q)-dependent phosphoinositide (PI) hydrolysis and 1,4,5-trisphosphate (IP(3))-dependent Ca²⁺release, and increases cytosolic free Ca²⁺. Motilin induces a biphasic, concentration-dependent contraction (EC₅₀= 1.0 +/- 0.2 nM), consisting of an initial peak followed by a sustained contraction^[2].

2699.07

Solid

C₁₂₀H₁₈₈N₃₄O₃₅S

52906-92-0

Phe-Val-Pro-Ile-Phe-Thr-Tyr-Gly-Glu-Leu-Gln-Arg-Met-Gln-Glu-Lys-Glu-Arg-Asn-Lys-Gly-Gln

FVPIFTYGELQRMQEKERNKGQ

胃动素 (人类，猪)

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)