6-Chloromelatonin

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6-Chloromelatonin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

63762-74-3

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

6-Chloromelatonin 是一种有效的褪黑素受体 (melatonin receptor) 激动剂，具有比褪黑素更高的代谢稳定性。6-Chloromelatonin 竞争 [³H] 褪黑素和 2-[¹²⁵I]- iodomelatonin 与 MT1 受体的结合 (pK_i分别为8.9 和 9.1)。6-Chloromelatonin 竞争 [³H] 褪黑素与 MT2 受体结合 (pK_i=9.77)。

生物活性

6-Chloromelatonin is a potentmelatonin receptoragonist with greater metabolic stability than melatonin. 6-Chloromelatonin compete for [³H]-melatonin and 2-[¹²⁵I]-iodomelatonin binding toMT1receptors (pK_i=8.9 and 9.1, respectively). 6-Chloromelatonin compete for [³H]-melatonin binding toMT2receptors (pK_i=9.77)^[1]^[2].

IC₅₀& Target^[1]

MT1

8.9 (pKi)

MT2

9.1 (pKi)

体外研究
(In Vitro)

6-Chloromelatonin competes for [³H]-melatonin binding sites in human platelet (K_i=11.4 nM)^[3].
6-chloromelatonin (10 pM, 1 nM, 100 nM, 10 μM; 72 hours) inhibits, in a dose-dependent manner, forskolin-stimulated hCG-beta secretion in JEG-3 and BeWo cells but had no effect on basal human chorionic gonadotrophin (hCG-beta) levels^[4].

体内研究
(In Vivo)

Rats injected with the melatonin agonist, 6-chloromelatonin (0.5 mg/kg) on the day after the phase shift has markedly higher excretion rates of 6-sulphatoxymelatonin compared to those of the controls^[5].

分子量

266.72

Formula

C₁₃H₁₅ClN₂O₂

CAS 号

63762-74-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.