TC-MCH 7c, a phenylpyridone derivative, is an orally available, selective and brain-penetrableMCH₁Rantagonist with anIC₅₀of 5.6 nM for hMCH₁R^[1]. TC-MCH 7c hasK_is of 3.4 nM and 3.0 nM of human and mouse MCH₁R, respectively^[2].

IC50: 5.6 nM (hMCH₁R)^[1]
Ki: 3.4 nM (hMCH₁R) and 3.0 nM (mouse MCH₁R)^[1]

TC-MCH 7c has an IC₅₀of 9.7 μM for MCH₁R in [Ca²⁺]i mobilization^[1].
TC-MCH 7c has IC₅₀s of 23 nM and 9.0 μM for FLIPR and hERG, respectively^[2].

TC-MCH 7c (oral; 3-30 mg/kg; once-daily for 1.5 months) exhibits excellent body weight reduction in a dose-dependent manner in DIO mice model^[1].
TC-MCH 7c (oral; 3-30 mg/kg) with 30 mg/kg has plasma concentrations of 5.1, 1.8, and 0.7 μM at 2, 15, and 24 hours, respectively^[2].

408.47

Solid

C₂₄H₂₅FN₂O₃

864756-35-4

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