Neuropeptide AF(cattle)

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

99588-52-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Neuropeptide AF (cattle) 是一种酰胺化的十八肽，是 RFamide 神经肽。Neuropeptide AF (cattle) 充当 Mas 相关基因受体 A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) (EC₅₀约为 60 nM) 和MrgprC11(EC₅₀约为 300 nM) 的配体。Neuropeptide AF (cattle) 也激活 G 蛋白偶联受体NPFF1(Neuropeptide Y Receptor) (EC₅₀约为 25-325 nM) 和NPFF2(EC₅₀约为 1-5 nM)。Neuropeptide AF (cattle) 显示出抗阿片和相关的疼痛调节作用。

生物活性

Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. Neuropeptide AF (cattle) acts as a ligand ofMas-related gene receptor A4 (MrgprA4)(Mas-related G-protein-coupled Receptor (MRGPR)) (EC₅₀of ~60 nM) andMrgprC11(EC₅₀of ~300 nM). Neuropeptide AF (cattle) also activate to the G protein-coupled receptorsNPFF1(Neuropeptide Y Receptor) (EC₅₀of ~25-325 nM) andNPFF2(EC₅₀of ~1-5 nM). Neuropeptide AF (cattle) shows anti-opiate and related pain modulation effects^[1]^[2].

体外研究
(In Vitro)

Neuropeptide AF (NPAF) (50, 100, 150, 300, and 600 nM) induces a piecemeal degranulation in bone marrow-derived mucosal mast cells (BMMCs). Neuropeptide AF can be considered as a novel modulator of BMMC activity in the neuro-immune communication in the gastrointestinal tract^[1].

体内研究
(In Vivo)

Neuropeptide AF (cattle) (0.25 μg/2 μL; i.c.v.; 30 min prior to the tests) decreases the immobility time and increases the climbing and swimming times in modified mouse forced swimming test (mFST)^[2].

Animal Model:	Male CFLP mice (25-28 g)^[2]
Dosage:	0.25 μg/2 μL
Administration:	i.c.v.; 30 min prior to the tests
Result:	Decreased the immobility time and increased the climbing and swimming times.

分子量

1920.13

Formula

C₈₉H₁₃₀N₂₄O₂₄

CAS 号

99588-52-0

Sequence Shortening

AGEGLSSPFWSLAAPQRF-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.