(R)-Bromoenol lactone ((R)-BEL) 是一种不可逆的、手性的、基于机制的钙非依赖性磷脂酶 γ (iPLA2γ) 抑制剂。
| Cas No. | 478288-90-3 |
| 别名 | (R,E)-Bromoenol lactone |
| Canonical SMILES | Br/C=C(CC1)/OC([C@@]1([H])C2=CC=CC3=CC=CC=C32)=O |
| 分子式 | C16H13BrO2 |
| 分子量 | 317.2 |
| 溶解度 | DMF: 50 mg/ml,DMSO: 25 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): .05 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components. The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). Unlike (S)-BEL, (R)-BEL does not inhibit iPLA2β except at high doses of 20-30 µM. (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 µM. |
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