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Hyocholic Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hyocholic Acid图片
CAS NO:547-75-1
包装与价格:
包装价格(元)
500μg电议
1mg电议
5mg电议
10mg电议

产品介绍
Cas No.547-75-1
别名猪胆酸,γ-Muricholic Acid
化学名(5β)-3α,6α,7α-trihydroxy-cholan-24-oic acid
Canonical SMILESC[C@H](CCC(O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)[C@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
分子式C24H40O5
分子量408.6
溶解度30 mg/ml in DMF, 20 mg/ml in DMSO, 20 mg/ml in Ethanol
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Hyocholic acid is a primary bile acid in pigs and other mammals. [1] It has also been found in urine samples from patients with cholestasis. [2] Hyocholic acid is converted by gut microflora primarily to taurohyocholate and, to a lesser extent, taurocholic acid and tauro-β-muricholic acid in mice.[3] Hyocholic acid has low toxicity against human hepatoma HepG2 cells.[3][4]

Reference
[1]. Lundell, K., and Wikvall, K. Species-specific and age-dependent bile acid composition: Aspects on CYP8B and CYP4A subfamilies in bile acid biosynthesis. Curr. Drug Metab. 9(4), 323-331 (2008).
[2]. van Berge Henegouwen, G.P., Brandt, K.H., Eyssen, H., et al. Sulphated and unsulphated bile acids in serum, bile, and urine of patients with cholestasis. Gut 17(11), 861-869 (1976).
[3]. Wang, D.Q.-H., Tazuma, S., Cohen, D.E., et al. Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: Studies in the gallstone-susceptible mouse. Am. J. Physiol Gastrointest. Liver Physiol. 285(3), G494-G502 (2003).
[4]. Perreault, M., Bialek, A., Trottier, J., et al. Role of glucuronidation for hepatic detoxification and urinary elimination of toxic bile acids during biliary obstruction. PLoS One 8(11), e80994 (2013).