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Glycohyocholic Acid
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Glycohyocholic Acid图片
CAS NO:32747-08-3
包装与价格：
包装价格(元)
500μg电议
1mg电议
5mg电议
10mg电议

产品介绍
糖球胆酸 (GHCA) 是初级胆汁酸球胆酸的甘氨酸共轭形式。
Cas No.32747-08-3
别名甘氨猪胆酸钠盐,Glycine Hyocholate
化学名N-[(3α,5β,6α,7α)-3,6,7-trihydroxy-24-oxocholan-24-yl]-glycine
Canonical SMILESO[C@@H]1CC[C@@]2(C)[C@@]([C@@H](O)[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC(NCC(O)=O)=O)([H])C1
分子式C26H43NO6
分子量465.6
溶解度20mg/mL in ethanol, 30mg/mL in DMSO, or in DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Glycohyocholic acid (GHCA) is a glycine-conjugated form of the primary bile acid hyocholic acid .[1] GHCA is upregulated 6.6-fold in the serum of patients with cirrhosis induced by hepatitis C virus (HCV) compared to healthy controls.[2] Plasma levels of GHCA increase in patients who are no longer diabetic following gastric bypass surgery.[3]

Reference:
[1]. Guo, L., Milburn, M.V., Ryals, J.A., et al. Plasma metabolomic profiles enhance precision medicine for volunteers of normal health. Proc. Nat. Acad. Sci. USA 112(35), E4901-E4910 (2015).
[2]. Fitian, A.I., Nelson, D.R., Liu, C., et al. Integrated metabolomic profiling of hepatocellular carcinoma in hepatitis C cirrhosis through GC/MS and UPLC/MS-MS. Liver Int. 34(9), 1428-1444 (2014).
[3]. Yu, H., Ni, Y., Bao, Y., et al. Chenodeoxycholic acid as a potential prognostic marker for roux-en-Y gastric bypass in chinese obese patients. J. Clin. Endocrinol. Metab. 100(11), 4222-4230 (2015).