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Murideoxycholic Acid
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Murideoxycholic Acid图片
CAS NO:668-49-5
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Murideoxycholic acid 是一种 6 β-羟基化胆汁酸。
Cas No.668-49-5
别名鼠脱氧胆酸
化学名5β-3α,6β-dihydroxy-cholan-24-oic acid
Canonical SMILESC[C@H](CCC(O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])C[C@@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
分子式C24H40O4
分子量392.6
溶解度20mg/mL in ethanol or DMSO, 30mg/mL in DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Murideoxycholic acid (MDCA) is a secondary bile acid produced from α-muricholic acid and β-muricholic acid.[1] It is also a metabolite of lithocholic acid in liver S9 fractions from humans and other species.[2] MDCA prevents gallstone formation in hamsters fed a lithogenic diet but does not resolve gallstones in prairie dogs fed a high cholesterol diet.[3],[4] Gallstones formed during MDCA administration after a high cholesterol diet are comprised of an insoluble calcium salt of murideoxycholyl taurine.[4] In humans, MDCA is rapidly absorbed and is metabolized as an endogenous bile acid with a half-life of approximately 3.5 days.[5]

Reference:
[1]. Wahlstrom, A., Sayin, S.I., Marschall, H.-I., et al. Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism. Cell Metab. 24(1), 41-50 (2016).
[2]. Thakare, R., Alamoudi, J.A., Gautam, N., et al. Species differences in bile acids II. Bile acid metabolism. J. Appl. Toxicol. 38(10), 1336-1352 (2018).
[3]. Cohen, B.I., Matoba, N., Mosbach, E.H., et al. Bile acids substituted in the 6 position prevent cholesterol gallstone formation in the hamster. Gastroenterology 98(2), 397-405 (1990).
[4]. Cohen, B.I., Ayyad, N., Mosbach, E.H., et al. Replacement of cholesterol gallstones by murideoxycholyl taurine gallstones in prairie dogs fed murideoxycholic acid. Hepatology 14(1), 158-168 (1991).
[5]. Khallou, J., Legrand-Defretin, V., Parquet, M., et al. Metabolism and time-course excretion of murideoxycholic acid, a 6 β-hydroxylated bile acid, in humans. J. Hepatol. 17(3), 364-372 (1993).