CFM 4 是 CARP-1/APC-2 结合的有效小分子拮抗剂。 CFM 4 阻止 CARP-1 与 APC-2 结合，导致 G2M 细胞周期停滞，并诱导细胞凋亡，IC50 范围为 10-15 μM. CFM 4 还抑制耐药人类乳腺癌细胞的生长。
| Cas No. | 331458-02-7 |
| 化学名 | 1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one |
| Canonical SMILES | ClC1=CC=CC=C1CN2C3=CC=CC=C3C4(NN=C(S4)C5=CC=CC=C5)C2=O |
| 分子式 | C22H16ClN3OS |
| 分子量 | 405.9 |
| 溶解度 | <8.12mg/ml in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
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