| Cas No. | 136560-76-4 |
| Canonical SMILES | CCCCCCCC/C=C\CCCCCCCC(N[C@@H](CC(C)C)C(O)=O)=O |
| 分子式 | C24H45NO3 |
| 分子量 | 395.6 |
| 溶解度 | DMF: 10 mg/ml,DMSO: 12 mg/ml,Ethanol: 12 mg/ml,Ethanol:PBS (pH 7.2) (1:4): 200 µ g/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | N-Oleoyl leucine is an N-acyl amide generated by PM20D1 that uncouples mitochondrial respiration independent of uncoupling protein 1 (UCP1) in vitro. N-Oleoyl leucine (25 mg/kg, i.p.) decreases body weight and food intake, preferentially decreasing fat mass in a diet-induced obesity mouse model. It improves glucose homeostasis in a fasting glucose tolerance test and increases VO2 while slightly decreasing overall locomotor activity. |
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