CAS NO: | 128312-51-6 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Ro 24-5913 (Cinalukast) is an orally active and potentLTD4antagonist with anIC50value of 6.4 nM. Ro 24-5913 can be used for the research of asthma[1]. | ||||||||
IC50& Target | IC50: 6.4 nM (LTD4)[1] | ||||||||
体外研究 (In Vitro) | Ro 24-5913 competes with [3H]LTD4 for its binding site in guinea pig lung membranes with an IC50value of 6.4 nM[1].Ro 24-5913 shows effective antagonist efficacy to LTD4-induced contractions with a pKBvalue of 9.3[1]. | ||||||||
体内研究 (In Vivo) | Ro 24-5913 (10 mg/kg i.v. and 100 mg/kg p.o.; once) inhibits LTD4-induced bronchoconstriction in guinea pigs with LD50s of 0.13 and 0.12 mg/kg for i.v. and p.o. respectively[1].
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分子量 | 412.55 | ||||||||
Formula | C23H28N2O3S | ||||||||
CAS 号 | 128312-51-6 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |