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Ro 24-5913
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ro 24-5913图片
CAS NO:128312-51-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
Cinalukast
产品介绍
Ro 24-5913 (Cinalukast) 是一种具有口服活性的,有效的LTD4拮抗剂,IC50值为 6.4 nM。Ro 24-5913 可用于哮喘的研究。
生物活性

Ro 24-5913 (Cinalukast) is an orally active and potentLTD4antagonist with anIC50value of 6.4 nM. Ro 24-5913 can be used for the research of asthma[1].

IC50& Target

IC50: 6.4 nM (LTD4)[1]

体外研究
(In Vitro)

Ro 24-5913 competes with [3H]LTD4 for its binding site in guinea pig lung membranes with an IC50value of 6.4 nM[1].
Ro 24-5913 shows effective antagonist efficacy to LTD4-induced contractions with a pKBvalue of 9.3[1].

体内研究
(In Vivo)

Ro 24-5913 (10 mg/kg i.v. and 100 mg/kg p.o.; once) inhibits LTD4-induced bronchoconstriction in guinea pigs with LD50s of 0.13 and 0.12 mg/kg for i.v. and p.o. respectively[1].

Animal Model:Guinea pigs[1]
Dosage:10 mg/kg
Administration:Oral gavage; 10 mg/kg once
Result:Inhibited LTD4-induced bronchoconstnction and antigen-induced bronchoconstnction in guinea pigs.
分子量

412.55

Formula

C23H28N2O3S

CAS 号

128312-51-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.