CAS NO: | 41443-28-1 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | ODQ is a potent and selectivesoluble guanylyl cyclase(sGC, nitric oxide-activated enzyme) inhibitor. ODQ enhances the pro-apoptotic effects of Cisplatin in human mesothelioma cells[1]. | ||||||||||||||||
体外研究 (In Vitro) | At 30 and 50 μM, ODQ causes significant induction of apoptosis in the NCI-H2452 cells, elevating apoptotic levels by 12 fold and 15 fold, respectively. At 10μM, a concentration below the threshold for induction of apoptosis by ODQ, ODQ in combination with Cisplatin enhanced (in fact, doubled) the pro-apoptotic effects of Cisplatin at 1 μM[1]. | ||||||||||||||||
体内研究 (In Vivo) | ODQ (2 mg/kg; i.p.) reduces the multiple organ injury and dysfunction caused by wall fragments of Gram-positive or Gram-negative bacteria in the anesthetized rat[2].
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Clinical Trial | |||||||||||||||||
分子量 | 187.15 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C9H5N3O2 | ||||||||||||||||
CAS 号 | 41443-28-1 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(534.33 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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