CID 2745687

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CID 2745687

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

264233-05-8

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

CID 2745687 是一种特异性、可逆和竞争性的GPR35拮抗剂，K_i为 12.8 nM。

生物活性

CID 2745687 acts as a specific, reversible and competitiveGPR35antagonist with aK_iof 12.8 nM^[1].

体外研究
(In Vitro)

For ERK1/2 phosphorylation with 1 μM Pamoic acid as the agonist, the CID 2745687 (CID2745687) K_iis 18 nM^[1]. CID 2745687 (CID-2745687) is a potent antagonist in β-arrestin-2 interaction assays only at human GPR35^[2].
Using the BRET-based GPR35-β-arrestin-2 interaction assay and an EC₈₀concentration of Zaprinast (20 μM) as agonist, CID 2745687 behaved as a moderately potent, concentration-dependent antagonist at human GPR35 with pIC₅₀=6.70±0.09^[2].
CID 2745687 (pIC₅₀=6.27±0.08) fully reverses the agonist action of Cromolyn disodium^[2].

体内研究
(In Vivo)

CID 2745687 (CID2745687; 1 mg/kg; administrated orally every day for the last 4 weeks), a specific GPR35 antagonist, reverses Lodoxamide-mediated anti-fibrotic effects^[3].

Animal Model:	Six-week-old male C57BL/6 mice^[3]
Dosage:	1 mg/kg
Administration:	Oral administration, every day for 4 weeks
Result:	Inhibited Lodoxamide-mediated protective effects.

分子量

395.43

Formula

C₁₇H₁₉F₂N₅O₂S

CAS 号

264233-05-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.