CAS NO: | 65373-29-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | MS21570 is a selectiveGPR171antagonist, with anIC50of 220 nM. | ||||||||||||||||
IC50& Target | IC50: 220 nM (GPR171)[1]. | ||||||||||||||||
体内研究 (In Vivo) | MS21570 significantly attenuates this CNO-mediated increase in food intake. Interestingly, MS21570 causes a significant increase in center time compared to vehicle suggesting an effect on the anxiety-like behavior. Intra-BLA administration of MS21570 leads to an increase in open arm time on the elevated plus maze although there is no effect on locomotor activity during this test. Interestingly, when administered before and immediately following fear conditioning, MS21570 significantly attenuates freezing measured 24 hours later. Behavioral differences between systemic and intra-BLA administration of MS21570 could be due to the pharmacokinetic and pharmacodynamic properties of the drug. Further studies are needed to characterize the GPR171 antagonist[1]. | ||||||||||||||||
分子量 | 237.34 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C10H11N3S2 | ||||||||||||||||
CAS 号 | 65373-29-7 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 125 mg/mL(526.67 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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