Oxyntomodulin (swine) 是GLP-1R(GLP-1 受体) 和GCGR(胰高血糖素受体) 的双重激动剂，是一种在餐后状态下从肠道释放的肽类激素。Oxyntomodulin (swine) 可抑制食欲，并减少食物摄入。
| 生物活性 | Oxyntomodulin (swine) is a dual agonist forGLP-1 receptor(GLP-1R) andglucagon receptor(GCGR), a peptide hormone released from the gut in post-prandial state. Oxyntomodulin (swine) suppresses appetite and reduces food intake[1][2][3]. |
体外研究
(In Vitro) | Oxyntomodulin (0-1000 nM; 24 or 48 h) promotes neural cell proliferation in a dose- and time-dependent manner[3].
Oxyntomodulin (0-1000 nM; 24 h) protects against glutamate toxicity and oxidative stress in neuronal cells[3].
Oxyntomodulin (100 nM; 24 h) reduces glutamate-mediated neurotoxicity in primary cortical neurons in a dose-dependent manner[3].
Cell Proliferation Assay[3] | Cell Line: | SH-SY5Y and SH-hGLP-1R #9 cells | | Concentration: | 0, 1, 10, 100, 1000 nM | | Incubation Time: | 24 or 48 h | | Result: | Increased cell viabilities at 24 h after treatment in hGLP-1R overexpressing #9 cells.
Enhanced cell viability in both SH-SY5Y and #9 cells at 48 h after treatment. |
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体内研究
(In Vivo) | Oxyntomodulin (intracerebroventricular administration; 20 μg per rat; once) treatment improves locomotor activity in stroke rats, and reduces cerebral infarction[3].
| Animal Model: | Transient middle cerebral artery occlusion (MCAo) rat model[3] | | Dosage: | 20 μg per rat | | Administration: | Intracerebroventricular administration; 20 μg per rat; once | | Result: | Increased horizontal activity, movement number, movement time, total distance travelled, vertical activity, vertical movement number, and vertical movement time, compared to vehicle control group.
Reduced the extent of cortical infarction compared to vehicle control group. |
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| Sequence Shortening | HSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNKNNIA |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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