Pemvidutide

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Pemvidutide

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2538014-94-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Pemvidutide 是一种GLP-1R/GCGR双重激动剂，可导致体重、肝脏脂肪和血清脂质的显著降低。Pemvidutide 可用于非酒精性脂肪性肝炎 (NASH) 和肥胖症的研究。

生物活性

Pemvidutide is aGLP-1R/GCGRdual agonist, shows striking reductions in body weight, liver fat and serum lipids. Pemvidutide can be used in non-alcoholic steatohepatitis (NASH) and obesity research^[1].

体内研究
(In Vivo)

Pemvidutide (subcutaneous injection; 5 or 10 nmol/kg; once daily; 12 w) treatment improves NASH (nonalcoholic steatohepatitis) outcomes in vivo^[1].

Animal Model:	C57BL6/J mice (with biopsy-confirmed NAS score after 29 weeks on a HFFC diet)^[1]
Dosage:	5 or 10 nmol/kg
Administration:	Subcutaneous injection; 5 or 10 nmol/kg; once daily; 12 weeks
Result:	Lowered hepatic lipids, liver weight, biomarkers of liver injury (plasma ALT and AST), the inflammation marker galactin-3, the fibrosis marker Col1a1, and the NAS score.

分子量

3873.35

Formula

C₁₈₂H₂₇₅N₃₉O₅₄

CAS 号

2538014-94-5

Sequence Shortening

H-{Aib}-QGTFTSDYSKYLDEKAAKEFIQWLLQT-NH2 (Lactam: Glu-16;Lys-20)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.