Apraglutide

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Apraglutide

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1295353-98-8

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议

产品名称

FE 203799

产品介绍

Apraglutide (FE 203799) 是一种合成的33-氨基酸肽和长效的 GLP-2类似物，能够增强全回肠切除的新生短肠综合征小猪的适应性和线性肠生长。

生物活性

Apraglutide (FE 203799), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum^[1].

体内研究
(In Vivo)

Apraglutide (FE 203799; 5 mg/kg/dose, subcutaneously, twice on days 0 and 4 postsurgery) treated piglets are healthy, have significant lower fecal fat and energy losses and exhibite intestinal lengthening, greater small-intestinal weight, longer villus height, and greater crypt depth on day 7^[1].

Animal Model:	NewbornDuroc piglets, 2–5 days old and weighing between 2-2.6 kg^[1].
Dosage:	5 mg/kg/dose.
Administration:	Subcutaneously, twice on days 0 and 4 postsurgery.
Result:	On day 7, treated piglets were healthy, had significant lower fecal fat and energy losses and exhibited intestinal lengthening, greater small-intestinal weight, longer villus height, and greater crypt depth.

Clinical Trial

分子量

3765.25

性状

Solid

Formula

C₁₇₂H₂₆₃N₄₃O₅₂

CAS 号

1295353-98-8

Sequence Shortening

HGDGSFSDEX FTILDLLAAR DFINWLIQTK ITD-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO : 100 mg/mL(26.56 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	0.2656 mL	1.3279 mL	2.6559 mL
5 mM	0.0531 mL	0.2656 mL	0.5312 mL
10 mM	0.0266 mL	0.1328 mL	0.2656 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。