GLP-1(7-37)acetate

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GLP-1(7-37)acetate

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1450806-98-0

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品介绍

GLP-1(7-37) acetate 是一种肠道胰岛素激素，可以增强葡萄糖诱导的胰岛素分泌。

生物活性

GLP-1(7-37) acetate is an intestinal insulinotropic hormone that augments glucose inducedinsulinsecretion^[1].

体内研究
(In Vivo)

GLP-1(7-37) (0.5, 5 or 50 pmol/min/kg) infused during the second hour of a 2-hour 11-mM hyperglycemic clamp produces a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion in rats^[2].
Infusion of GLP-1(7-37) (5 pmol/min/kg) from 1 hour through 7 hours produces a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle in rats with maintained glucose concentration at 11 mM^[2].

Animal Model:	Male Sprague-Dawley rats weighing 300 to 350 g with glucose IV at a variable rate for 7 hours to maintain plasma glucose concentration at 11 mM^[2].
Dosage:	5 pmol/min/kg.
Administration:	IV from 1 hour through 7 hours^[2].
Result:	Produced a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle.

Animal Model:	Male Sprague-Dawley rats weighing 300 to 350 g with maintained plasma glucose concentration at 11 mM^[2].
Dosage:	0.5, 5 or 50 pmol/min/kg.
Administration:	IV during the second hour of a 2-hour 11-mmol/L hyperglycemic clamp.
Result:	Produced a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion.

分子量

3415.72

性状

Solid

Formula

C₁₅₃H₂₃₂N₄₀O₄₉

CAS 号

1450806-98-0

Sequence

His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly

Sequence Shortening

HAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据

In Vitro:

H₂O : 50 mg/mL(14.64 mM;ultrasonic and adjust pH to 1 with HCl)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	0.2928 mL	1.4638 mL	2.9276 mL
5 mM	0.0586 mL	0.2928 mL	0.5855 mL
10 mM	0.0293 mL	0.1464 mL	0.2928 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.
请依序添加每种溶剂： PBS
Solubility: 12.5 mg/mL (3.66 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。