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Seconeolitsine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Seconeolitsine图片
CAS NO:2650074-56-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Seconeolitsine,一种抗生素,是一种靶向拓扑异构酶 I(TopA)的抑制剂。Seconeolitsine 也是一种新的抗菌剂,可以抑制S. pneumoniae的生长。Seconeolitsine 具有抑制 TopA 的活性,其 b>IC50值为 17 μM。Seconeolitsine 可用于对其他抗生素耐药的肺炎链球菌感染的研究。
生物活性

Seconeolitsine, anantibiotic, and is an inhibitor of targetingtopoisomeraseI (TopA). Seconeolitsine also is a new antimicrobial agent that can inhibitS. pneumoniaegrowth. Seconeolitsine can inhibit TopA relaxation activity with anIC50value of 17 μM. Seconeolitsine can be used for the research ofS. pneumoniaeinfections resistant toother antibiotics[1].

IC50& Target

Topoisomerase I

17 μM (IC50)

体外研究
(In Vitro)

Seconeolitsine (compounds 17) inhibits TopA relaxation activity in a concentration-dependent manner, with an IC50value of 17 μM and the inhibition of TopA is enhanced by preincubation of the enzyme with the alkaloid[1].
Seconeolitsine shows great inhibition ofS.pneumoniaegrowth with MIC50values of 16 μM for R6, ATCC6303, CipS8, CipS9, CipR20, CipR16, CipR8, CipR45 and CipR5. And shows great inhibition ofS. pneumoniaegrowth with MIC50values of 8 μM for CipR42, CipR68 and CipR15[1].
Seconeolitsine has activation at low concentrations and partial inhibition at 50 μM, a concentration at which the pneumococcal TopA showed full inhibition, but not inhibits Human TOPO1[1].
Seconeolitsine (0.25×-1×MIC) affects cell growth and division in a concentration-dependent manner[1].
Seconeolitsine (30 and 100 μM), is not affected neutrophil apoptosis and human cell viability[1].

体内研究
(In Vivo)

Seconeolitsine (compounds 17) increases supercoiling and TopA is target in vivo[1].

分子量

323.34

Formula

C19H17NO4

CAS 号

2650074-56-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.