| CAS NO: | 87-52-5 |
| 包装: | 20mg |
| 市场价: | 3119元 |
| Cas No. | 87-52-5 |
| 别名 | 芦竹碱,Donaxine |
| 化学名 | 1-(1H-indol-3-yl)-N,N-dimethylmethanamine |
| Canonical SMILES | CN(C)CC1=CNC2=CC=CC=C21 |
| 分子式 | C11H14N2 |
| 分子量 | 174.24 |
| 溶解度 | ≥ 17.4mg/mL in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Gramine (Donaxine) is a natural alkaloid isolated from giant reed[2], acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively[1]. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist[2]. Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties[1]. Gramine is an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively[1]. Gramine is a potential β2-AR agonist[2].Gramine (20 μM to 1.2 nM) dose-dependently inhibits the growth of AdipoR1/adipoR2-positive cancer cell lines (MDA-MB-231 and MCF-7 cells), with IC50s of 9.6±0.9 and 0.1±0.1 μM, respectively[1]. References: |
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